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Project
Acronym: COST Action CM0701  
Name: Cascade Chemoenzymatic Processes - New Synergies Between Chemistry and Biochemistry 
Project status: From: 2012-04-18 To: 2012-04-17 (Completed)
Contract number:  
Action line:  
Type (Programme): MULTILAT 
Instrument: COST 
Project cost: -
Project funding: -
Project coordinator
Organisation Name: Istituto di Chimica del Riconoscimento Molecolare 
Organisation adress: C.N.R. Via Mario Bianco 9, 20131 Milano 
Organisation country: Italija 
Contact person name: Sergio Riva 
Contact person email: Email 
Croatian partner
Organisation name: Fakultet kemijskog inženjerstva i tehnologije 
Organisation address: Marulićev trg 19 
Contact person name: Đurđa Vasić-Rački
Contact person tel:
+385 1 4597 104  Contact person fax: +385 1 4597 133 
Contact person e-mail: Email 
Partners
Organisation nameCountry
Division of Food Biotechnology BOKU - University of Natural Resources and Applied Life Sciences  Austrija 
Bio/Technology Research GroupInstitute of BiotechnologyGraz University of Technology Austrija 
Flemish Institute for Technological Research (VITO) N/A Belgija 
University of Chemical Technology and Metallurgy  Bugarska 
Institute of Microbiology Academy of Sciences of the Czech Republic, Center of Biocatalysis and Biotransformation Češka Republika 
Institute of Experimental Botany of the Academy of Sciences of the Czech Republic Češka Republika 
Institute of Microbiology Laboratory of Biotransformation Češka Republika 
Aalborg University Section of Biotechnology Njemačka 
Technical University of Denmark Department of Chemical and Biochemical Engineering Njemačka 
Laboratory of Synthetic Drug ChemistryUniversity of Turku  Finska 
Mass and Heat Transfer Process LaboratoryUniversity of Oulu  Finska 
Laboratoire dIngenierie des Systemes Biologiques et Physiques  Francuska 
Institut fur Organische ChemieTU Darmstadt  Njemačka 
Institut fur Bio- und Lebensmitteltechnik Lehrstuhl fur Technische BiologieUniversitat Karlsruhe Njemačka 
Tel Aviv University Tel Aviv University, School of Computer Science Izrael 
Politecnico di Milano via Mancinelli Italija 
Institute of Biochemistry, Vilnius Litva 
Biotechnology group, Groningen Biomolecular Sciences and Biotechnology InstituteUniversity of Groningen  Nizozemska 
Delft University of Technology  Nizozemska 
University of Bucharest, Faculty of Chemistry Rumunjska 
Centre for Applied Biochemistry and Biotechnology Rumunjska 
Consejo Superior de Investigaciones Cientificas (CSIC)Institute for Chemical and Environmental Research, Barcelona  Španjolska 
Universidad de Almeria Edificio C.I.T.E.I., Almeria Španjolska 
Royal Institute of Technology (KTH) AlbaNova University  Švedska 
University of Berne Department of Chemistry and BiochemistryFreiestrasse  Švicarska 
Sigma-Aldrich Research Specialities,Buchs  Švicarska 
Middle East Technical University Inonu Bulvari, Ankara  Turska 
Short description of project
 The main objective of the Action is to increase the innovative potential of biocatalysis by promoting the multistep catalytic concept, thus bringing this methodology closer to the application sphere.The integration of biocatalysis into chemical processes is one of the three pillars (the Industrial Biotechnology pillar) of the European Platform on Sustainable Chemistry. This methodology also belongs to the fundamental strategies of Green Chemistry.Therefore, this COST Action (acronym CASCAT) aims to enhance the synthetic potential of biocatalysis by coupling biotransformations one to another and integrating them with chemical steps to increase the product purity and yields close to quantitative values. A multidisciplinary approach is required to achieve this goal, involving precursor synthesis, enzyme screening, heterologous protein expression, enzyme mutagenesis, biocatalyst (co)-immobilization, bioreactor design and chiral product analysis.CASCAT will consist of four Working Groups applying the multi-step approach to the synthesis/modification and transfer of glycosyl donors/acceptors, the deracemization of amino acids by multiple hydrolase systems, the synthesis of valuable amides and carboxylic acids from cheap chemicals (e.g. aldehydes) via combined action of enzymes involved in nitrile metabolism and entry or follow-up (chemo)enzymatic steps, the development of novel paths to biologically relevant chiral compounds using multienzyme-carboligation reactions or in situ cofactor regeneration.This research will focus on the production of bioactive target molecules (e.g., non-natural amino-acids, glycoconjugates and mimetics, flavonoids, steroids) and chiral precursors of enantiopure pharmaceuticals.Keywords: Cascade reactions, Multistep enzymatic transformations, Biocatalysis, Industrial Biotechnology, Sustainable Chemistry 
Short description of the task performed by Croatian partner
  


   

 


Design by: M. Mačinković

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