Name: Sustainable industrial processes based on a C-C bond-forming enzyme platform 
Project status: From: 2015-04-01 To: 2019-03-31 (Completed)
Contract number: 635595 
Action line: H2020-LEIT-BIO-2014-1 
Type (Programme): HORIZON 2020 
Instrument: IP 
Project cost: 9.251.355,00 EUR
Project funding: 8.202.966,00 EUR
Project coordinator
Organisation Name: Technical University of Darmstadt 
Organisation adress: Karolinenplatz 5, Darmstadt 64289 
Organisation country: Germany 
Contact person name: prof. dr. sc. Wolf-Dieter Fessner 
Contact person email: Email 
Croatian partner
Organisation name: Fakultet kemijskog inženjerstva i tehnologije 
Organisation address: Marulićev trg 19, 10000 Zagreb 
Contact person name: Izv. prof. dr. sc. Zvjezdana Findrik Blažević
Contact person tel:
+38514597157  Contact person fax:  
Contact person e-mail: Email 
Organisation nameCountry
Institute of Advanced Chemistry of Catalonia - CSIC Spain 
Autonoma University of Madrid Spain 
Technical University Braunschweig Germany 
University of Groningen Netherlands 
Biochemize, S.L. Spain 
Bio-Prodict, B.V. Netherlands 
Sustainable Momentum, S.L. Spain 
Institute Univ. de Ciencia i Technologia, S.A. Spain 
Enzymicals Germany 
University of Freiburg Germany 
Prozomix United Kingdom 
Evonik Germany 
Short description of project
C-C bond forming reactions are at the heart of industrial organic synthesis, but remain largely unexplored due to long development timelines and the lack of broad biocatalytic reaction platforms. CARBAZYMES addresses these challenges by assembling an interdisciplinary and intersectoral consortium as a powerful synergistic tool to promote innovation in the field of biocatalytic C-C bond formation at large scale, and thus the global competitiveness of the European chemical and pharmaceutical industry. The proposed consortium, with 50% industrial participation, represents academia but also commercial interests in different stages of the research-to-market process. This top-down approach, together with a lifecycle innovation approach ensures an industrial drive to the project. Clearly aligned with the scope of topic BIOTEC3-2014, CARBAZYMES will pursue the biocatalytic synthesis (spanning TRLs 5-7) of 4 APIs and 3 bulk chemicals –corresponding to market needs detected by the industrial partners in the Consortium. This will be accomplished through an inter-disciplinary approach which includes: i) a broad platform of 4 types of unique C-C bond-forming enzymes, mostly lyases; ii) the capacity to rapidly evolve enzymes to operate under industrial conditions by means of novel enzyme panels and massive screening methods; iii) application of microreactor technology for bioprocess characterization; iv) demonstration actions comprising technical (up to 100L) and economic viability studies carried out by industrial partners. CARBAZYMES unmistakably aims to have social and economic impact by addressing markets worth bn €, developing enzyme evolution technologies beyond the state of the art and creating qualified jobs and technical-scale facilities at the industrial partners’ sites. CARBAZYMES will also achieve an environmental impact by enforcing that the developed processes replace more energy and resource intensive processes, thus leading to reduced environmental footprints.  
Short description of the task performed by Croatian partner


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