Name: Glycosylation and Human Lectins in Rheumatoid Disease 
Project status: From: 2001-04-01 To: 2005-04-01 (Completed)
Type (Programme): BILAT 
Project funding: -
International partner
Organisation Name: Johns Hopkins University 
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Organisation country: Sjedinjene američke države 
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Croatian partner
Organisation name: Farmaceutsko-biokemijski fakultet 
Organisation address:  
Contact person name: Lauc, Gordan
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Contact person e-mail: Email 
Short description of project
Long term objective of this project is to understand changes in glycoconjugates and their interactions with lectin receptors in rheumatoid, and other diseases. Rheumatoid diseases are known to be associated with changes in oligosaccharide structures, but very little is know about effects of these changes on the interaction between glycoconjugates and their lectin receptors. One of the main problems is the lack of adequate methods for the analysis of lectin activity in complex biological samples, and we shall focus significant efforts to development and improvement of these methods. A novel set of compounds, named glycoprobes, will be used to identify and purify lectins that bind to specific carbohydrate structures. Individual lectins will be characterized by MALDI-MS, and their identity determined by peptide mapping. We hope that the information about changes in the activity of lectins in rheumatoid diseases will, in the long run, help identify future targets for more specific therapy of rheumatoid diseases. This research will be done primarily in Croatia as an extension of NIH grant # R01 DK09970 
Short description of the task performed by Croatian partner


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