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In the future the developed countries will be confronted with a growing number of elderly people due to a constant increase of the incidence of aging related diseases. In recent years, substances of natural origin have gained a lot of importance because of their potential use as prophylactic and therapeutic agents that may help to slow down aging process and provide a better quality of life for elderly patients. Oxidative stress is associated with pathogenetic mechanisms of many diseases including atherosclerosis, neurodegenerative diseases, cancer, diabetes and inflammatory disorders, as well as aging processes. The plant kingdom offers a wide range of compounds which can delay, inhibit or prevent the oxidation of oxidizable materials by scavenging free radicals and diminishing oxidative stress. The aim of the project is to discover and isolate various polyphenols, terpenes and alkaloids from natural resources, determine their chemical structures and biological activities, and specify the possible mechanisms of actions. The research will be directed towards natural products with antioxidative, antineurodegenerative, anti-inflammatory, immunomodulatory, antitumor and antimicrobial activities. Various methods for isolation, purification and structural elucidation of bioactive plant secondary metabolites as well as different in vitro assays will be applied. By discovering biologically most efficient natural substances, new possibilities will arise for their implementation in prevention and therapy of various acute and chronic diseases. Isolated bioactive substances with determined structural and biological characteristics might become the leading components in research and development of new synthetic drugs.
Short description of the task performed by Croatian partner
Ovo web sjedište koristi tehnologiju "kolačića" (eng. cookie) da bi se korisnicima prikazao dinamičan i personaliziran sadržaj, te su oni nužni za ispravan rad. Ako nastavite pregledavati ove stranice, kolačići će biti korišteni u suradnji s vašim preglednikom Weba.
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