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Project
Acronym: MAGISTER  
Name: Magnetic scaffolds for in vivo tissue engineering  
[ | CORDIS URL]
Project status: From: 2008-12-01 To: 2012-11-30 (Completed)
Contract number: 214685  
Action line: FP7-NMP  
Type (Programme): FP7 
Funding scheme: IP 
Project cost: 11.085.124,00 EUR
Project funding: 8.278.091,00 EUR
Project coordinator
Organisation Name: CONSIGLIO NAZIONALE DELLE RICERCHE 
Organisation adress: Piazzale Aldo Moro, Roma 
Organisation country: Italija 
Contact person name: Valentin DEDIU 
Contact person email: Email 
Croatian partner
Organisation name: Medicinski fakultet 
Organisation address: Šalata 3, Zagreb 
Contact person name: Mislav JELIC
Contact person tel:
+385-0-98221805   Contact person fax: +385-14818810 
Contact person e-mail: Email 
Partners
Organisation nameCountry
Short description of project
The main driving idea of the project is the creation of conceptually new type of scaffolds able to be manipulated in situ by means of magnetic forces. This approach is expected to generate scaffolds with such characteristics as multiple use and possibly multipurpose delivery in order to repair large bone defects and ostheocondral lesions in the articular surface of the skeletal system. The major limitations of the scaffolds for bone and cartilage regeneration nowadays available in the market are related to the difficulties in controlling cell differentiation and angiogenesis processes and to obtain stable scaffold implantation in the pathological site. . . Several attempts have been performed over the last years in order to provide scaffolds for tissue engineering, but nowadays there is no way to grant that tissue regeneration take place in the pathological site. The provision in vivo of the scaffold with staminal cells or /and growth factors in order to drive the tissue differentiation process and parallel angiogenesis represents nowadays one of most challenging requests [Ref. Nanomedicine roadmap]. The Consortium aims to elaborate, investigate and fabricate new kind of scaffolds magnetic scaffolds (MagS) - characterized by strongly enhanced control and efficiency of the tissue regeneration and angiogenic processes. The magnetic moment of the scaffolds enables them with a fascinating possibility of being continuously controlled and reloaded from external supervising centre with all needed scaffold materials and various active factors (AF). Such a magnetic scaffold can be imagined as a fixed station that offers a long-living assistance to the tissue engineering, providing thus a unique possibility to adjust the scaffold activity to the personal needs of the patient.    
Short description of the task performed by Croatian partner
 


   

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