| Project |
| Acronym: |
|
| Name: |
DEVELOPMENT OF NANOSTRUCTURED CATALYST-BASED SENSORS FOR ELECTROCHEMICAL DETECTION OF HYDROGEN PEROXIDE
|
| Project status: |
From: 2007-01-01
To: 2008-12-31
(Completed)
|
| Type (Programme): |
BILAT |
| Project funding: |
- |
| International partner |
| Organisation Name: |
Faculty of Chemistry and Chemical Technology, University of Ljubljana |
| Organisation adress: |
Askerceva cesta 5, SI-1000 Ljubljana |
| Organisation country: |
Slovenija |
| Contact person name: |
Boris Pihlar |
| Contact person email: |
Email |
| Croatian partner |
| Organisation name: |
Prehrambeno-biotehnološki fakultet |
| Organisation address: |
Pierottijeva 6, HR-10000 Zagreb |
| Contact person name: |
Damir Ivekovic
|
| Contact person tel: |
| +385 1 4605 292 |
Contact person fax: |
+385 1 4836 083 |
|
| Contact person e-mail: |
Email |
| Short description of project |
| Development of electrochemical sensors for sensitive and selective determination of hydrogen peroxide has a great practical importance because the amperometric hydrogen peroxide sensor is an essential part of oxidase enzyme-based biosensors. It serves as an electrochemical transducer that generates current proportional to the concentration of hydrogen peroxide, formed during the enzyme-catalyzed oxidation of enzymatic substrate (i.e. the analyte). The major problem in amperometric hydrogen peroxide detection is that at ordinarily employed electrode materials oxidation or reduction of hydrogen peroxide requires a high overpotential. Consequently, the sensor must be operated at a relatively high anodic or cathodic potential. At these potentials, many interfering species, usually present in real samples, may react at the electrode simultaneously with hydrogen peroxide, causing the loss of sensitivity and decreasing the accuracy of analysis. One of the most promising strategies to lower the potential for detection of hydrogen peroxide is the use of catalysts for electrochemical oxidation or reduction of hydrogen peroxide.
The objectives of the proposed project are:
(1) to develop novel nanostructured catalytic materials for electrochemical oxidation and reduction of hydrogen peroxide and
(2) to apply them in the construction of highly sensitive and selective hydrogen peroxide sensors and biosensors based on hydrogen peroxide producing enzymes.
More specifically, the research will be focused on the use of recently discovered titanate nanotubes (TiNT) as the support for deposition of noble metal and transition metal hexacyanoferrate (MeHCF) nanoparticles. The aim is to take advantage of both the high specific surface area of TiNT (up to 400 m2/g) and their chemical properties (ion exchange capabilities and high density of surface OH groups) to obtain novel high surface area catalytic materials that allow the covalent linkage of enzymes to their surface. |
| Short description of the task performed by Croatian partner |
| (1) Deposition of noble metal and metal hexacyanoferrate nanoparticles on the surface of TiNT by:
incorporation of noble metal cations into the structure of TiNT by ion-exchange and subsequent chemical reduction of exchanged cations,
surface precipitation of noble metal nanoparticles
(2) Chemical modification of the surface of TiNT with functionalized silanes and covalent linkage of selected enzymes to the modified surface. |
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